Brushfield spots in Down's syndrome

Brushfield spots are small white or grayish/brown spots on the periphery of the iris in the human eye due to aggregation of connective tissue, a normal iris element. These spots are normal in children but are also a feature of the chromosomal disorder Down syndrome. They occur in 35-78% of newborn infants with Down syndrome.They are much more likely to occur in Down syndrome children of the Caucasian race than children of Asian heritage.Brushfield spots are named after the physician, Thomas Brushfield, who first described them in his 1924 M.D. thesis.They are focal areas of stromal hyperplasia, surrounded by relative hypoplasia and are more common in patients with lightly pigmented irises.