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Showing posts from January, 2017

Helminths causing human infestaion and infections

1 NEMATODES Roundworm: Ascaris lumbricoides Hook worm: Necator americanus and Ancylostoma duodenale Pinworm: Enterobius vermicularis Thread worm: Strongyloides stercoralis Filarial worm: Wuchereria bancrofti, Brugia malayi, Onchocerca volvulus Whipworm: Trichuris trichiura Trichina worm: Trichinella spiralis Guinea worm: Dracunculus medinensis 2 TREMATODES Blood fluke: Schistosoma haematobium, mansoni, and japonicum Lung fluke: Paragonimus westermani Liver fluke: Fasciola hepatica 3 CESTODES Pork tapeworm: Taenia solium Beef tapeworm: Taenia saginata Fish worm: Diphyllobothrium latum Dog tapeworm: Echinococcus granulosus Dwarf tapeworm: Hymenolepis nana

Phases of Kortokoff's sound explained by a beautiful illustration from frozen

1. Phase I—The first appearance of faint, repetitive, clear tapping sounds which gradually increase in intensity for at least two consecutive beats is the systolic blood pressure. 2. Phase II—A brief period may follow during which the sounds soften and acquire a swishing quality. 3. Phase III—The return of sharper sounds, which become crisper to regain, or even exceed, the intensity of phase I sounds. 4. Phase IV—The distinct abrupt muffling of sounds, which become soft and blowing in quality. 5. Phase V—The point at which all sounds finally disappear completely is the diastolic pressure.

Pharmacokinetics of Chloroquine

Rapidly and completely absorbed by oral route Very large volume of distribution: loading dose is necessary Concentrated in erythrocytes, liver, spleen, kidney, lung, melanin-containing tissues Retina accumulation: ocular toxicity on long term use Partly metabolised by hepatic mixed function oxidase system Metabolites and parent drug excreted in urine