Widely prescribed anti-diabetes drug pioglitazone and its combinations
were banned on June 26 by Governemnt of India. Along with this, painkiller
analgin and anti-depressant deanxit(Flupenthixol+ Melitracen) were also
banned under Section 26A of the Drugs and Cosmetics Act(1940) by ministry of
health and family welfare, India.
Pioglitazone's safety : Always a concern
Pioglitazone is an anti-diabetic
drug, which has unique action on improving insulin resistance by acting on PPAR
receptors. Studies have reported pioglitazone causes congestive heart failure
due to fluid retention and also bladder cancer. It also causes muscle aches, headache, nausea,
vomiting, loss of appetite, pain in the abdomen etc. Three years ago another
drug from this family, rosiglitazone was banned in India following a decision
taken in European Union. Following
the reports of adverse effects, France has discontinued Pioglitazone, but USA
and UK allowed restricted use of Pioglitazone with a black box warning. .
Pioglitazone ban pricks patients
Ban on pioglitazone
may affect 700-crore market. The patients now don’t have much
options other than to resorting to costlier insulins or gliptins. The ban is
also viewed by many as a partisan decision, that is going to benefit particular
companies. There is protest surrounding the ban on pioglitazone and protesters claim that it will be a burden on
patients as they have to opt for expensive drugs. Some doctors also suggest that there
could have been an option to use pioglitazone at lower dosage with controlled
monitoring of adverse effects. It is said that Indians have more insulin resistance and pioglitazone is effective and affordable option for majority of
the patients.
Pioglitazone may still persist
Three weeks after the ban sources from ministry said that it may revoke the ban for restricted
use with the warning about adverse effects. The reason behind this decision is
that there is no affordable alternative to this widely used drug in India.
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