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Hy's Rule for hepatotoxicity

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Named after Hyman Zimmerman,  Hy's rule states that drug induced hepatotoxicity with
  1. Elevation of serum ALT : >3 times the upper limit of normal
  2. Elevation of serum bilirubin : > 2 times the upper limit of normal
The above two findings are associated with mortality rate of at least 10%.
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