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Vasomotor reversal of dale

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A very simple explanation for vasomotor reversal of Dale
  • Adrenaline/Epinephrine: Blood pressure changes has biphasic response 
  • Initially adrenaline concentration is high: acts on both alpha and beta receptors 
  • Alpha action predominates resulting in vasoconstriction and increase in BP 
  • Adrenaline action is rapidly reduced due to uptake and metabolism 
  • At lower concentrations: beta action predominates 
  • Resulting in vasodilation and reduction in BP 
Vasomotor reversal of Dale 
  • Phenoxybenzamine abolishes biphasic response 
  • As alpha receptors are blocked; blood pressure only falls (beta receptors)
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