A very simple explanation for vasomotor reversal of Dale Adrenaline/Epinephrine: Blood pressure changes has biphasic response Initially adrenaline concentration is high: acts on both alpha and beta receptors Alpha action predominates resulting in vasoconstriction and increase in BP Adrenaline action is rapidly reduced due to uptake and metabolism At lower concentrations: beta action predominates Resulting in vasodilation and reduction in BP Vasomotor reversal of Dale Phenoxybenzamine abolishes biphasic response As alpha receptors are blocked; blood pressure only falls (beta receptors)
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