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Showing posts from February, 2017

Vasomotor reversal of dale

A very simple explanation for vasomotor reversal of Dale Adrenaline/Epinephrine: Blood pressure changes has biphasic response  Initially adrenaline concentration is high: acts on both alpha and beta receptors  Alpha action predominates resulting in vasoconstriction and increase in BP  Adrenaline action is rapidly reduced due to uptake and metabolism  At lower concentrations: beta action predominates  Resulting in vasodilation and reduction in BP  Vasomotor reversal of Dale  Phenoxybenzamine abolishes biphasic response  As alpha receptors are blocked; blood pressure only falls (beta receptors)